Program

- short presentation (15 minutes)
- long presentation (20 minutes)

Wednesday, June 8

Inn at Darden Conference Center
2:00 PM – 4:00 PM Registration in lobby
Dorm guests will check in and get keys
Coffee and refreshments
2:00 PM – 3:45 PM Set up posters, Vendor exhibits
4:00 PM – 4:10 PM Welcome
Dr. Phillip A. Parrish
VP Research
University of Virginia

Introduction: Mark Yeager
4:10 PM – 5:10 PM Tony Kossiakoff – Keynote Speaker
Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics at University of Chicago
New and improved synthetic antibodies that facilitate structural analyses of functional conformational intermediates by both crystallography and Cryo-EM

Introduction: Zygmunt Derewenda
5:10 PM – 6:10 PM Edward Egelman – Keynote Speaker
Department of Biochemistry and Molecular Genetics at University of Virginia
Cryo-EM of Helical Polymers at Near-Atomic Resolution: New Insights into Evolutionary Divergence

Introduction: Wladek Minor
6:30 PM Dinner buffet

Thursday, June 9

Inn at Darden Conference Center
8:00 AM – 9:00 AM Continental Breakfast
9:00 AM – 10:15 AM Session Ia
Chair: Malgorzata Latallo
  • George Lountos
    Basic Science Program at Leidos Biomedical Research, Inc.
    Discovery of an Allosteric Inhibitor of the SUMO-Conjugating E2 Enzyme Ubc9 by Crystallographic Fragment Screening
  • Malwina Radwanska
    Dept. of Biochemistry and Molecular Genetics at University of Virginia
    Towards design of new reagents for the detection of the Ebola virus
  • Kurt Piepenbrink
    The Institute of Human Virology at The University of Maryland School of Medicine
    Diverse Type IV Pili in Multidrug-resistant Acinetobacter Mask Potential Antigenic Epitopes through C-terminal O-Glycosylation
10:15 AM – 10:30 AM Coffee break
10:30 AM – 12:10 AM Session Ib
Chair: Kasia Handing
  • Andres Wong
    Biology at Georgia State University
    Highly resistant HIV-1 proteases and strategies for their inhibition
  • William Tolbert
    Department of Biochemistry and Molecular Biology at Institute of Human Virology/University of Maryland School of Maryland
    Uncovering the Co-Receptor Binding Site of HIV-1 Envelope for Antibody-Dependent Cell-Mediated Cytotoxicity
  • Ryan Davis
    Biochemistry at Wake Forest School of Medicine
    Structural Insight into dsDNA Degradation by TREX1
  • Jordan Mancl
    Biological Sciences at Virginia Tech
    ­­­­­Crystal Structure of a Type IV Pilus Assembly ATPase: Insights into the Molecular Mechanism of PilB from Thermus thermophilus
  • Manisha Shrestha
    Biological Sciences at Virginia Tech
    A molecular approach to study the regulation of expression of Type Three Secretion System in Pseudomonas aeruginosa
12:10 AM Buffet lunch amongst posters and Vendor exhibits
1:30 PM – 3:10 PM Session IIa
Chair: Bartek Blus
  • Konstantin Korotkov
    Molecular & Cellular Biochemistry at University of Kentucky
    Structural basis of transmembrane protein translocation by mycobacterial ESX secretion systems
  • Jonathan Wagner
    Molecular Physiology and Biological Physics at University of Virginia
    Mechanism of higher order self assembly of the retroviral restriction factor TRIM5alpha
  • Sandra Postel
    Institute of Human Virology at University of Maryland Baltimore
    Structure of the flagellar capping protein from Pseudomonas aeruginosa
  • Ewa Niedzialkowska
    Molecular Biology and Biological Physics at University of Virginia
    Structural and biochemical characterization of novel glyoxalases from pathogenic bacteria.
3:10 PM – 3:30 PM Coffee break
3:30 PM – 4:50 PM Session IIb
Chair: Caitlin Hubbard
  • Sayan Chakraborty
    Molecular and Structural Biochemistry at North Carolina State University
    The role of post-translationally modified CLE peptides and BAM1 receptor kinase in plant meristem development
  • Zhipu Luo
    Synchrotron Radiation Research Section, Macromolecular Crystallography Laboratory at National Cancer Institute
    Detection of twinning in macromolecular crystallography
  • Edward Pryor
    R&D at Anatrace
    An update on detergent usage in membrane protein structural biology
  • Marek Grabowski
    Molecular Physiology and Biological Physics at University of Virginia
    A public database of macromolecular diffraction experiments
5:00 PM – 6:30 PM Wine & Cheese Courtyard reception indoor/outdoor amongst posters and vendor exhibits
Attendees are free to explore Charlottesville for dinner at any of the fine restaurants.

Friday, June 10

Inn at Darden Conference Center
8:00 AM – 9:00 AM Continental Breakfast
Dorm guests must check out and turn in keys
9:00 AM – 10:20 AM Session IIIa
Chair: Andrea Moon
  • Ivan Shabalin
    Molecular Physiology and Biological Physics at University of Virginia
    Quality of protein crystal structures for drug discovery: misidentified and wrongly modelled ligands
  • Kimberly Stanek
    Chemistry at University of Virginia
    Crystal structures and RNA-binding properties of two Hfq homologs from Aquifex aeolicus
  • M.Gordon Joyce
    Virology Lab/ Structural Biology Section at Vaccine Research Center, NIAID, NIH
    Vaccine-Induced Antibodies that Neutralize Group 1 and 2 Influenza A Viruses
  • Caleb Schlachter
    Biochemistry at University of South Carolina
    Comparison of structures and functions of 2-methylcitrate synthase (mcsA) from Aspergillus fumigatus and citrate synthase (hCS) from humans
10:20 AM – 10:30 AM Coffee break
10:30 AM – 11:50 AM Session IIIb
Chair: Caleb Shlachter
  • Iga Kucharska
    Molecular Physiology and Biological Physics at University of Virginia
    Structure and function of the outer membrane protein OprG from Pseudomonas aeruginosa
  • Rafal Zdanowicz
    Department of Chemistry at University of Virginia
    Membrane and SNARE complex interactions of complexin-1.
  • Blazej Skrobek
    Biochemistry and Molecular Biology at The University of Chicago
    Stabilization of the asymmetric state of magnesium ion channel CorA with synthetic antibodies
  • Przemyslaw Porebski
    Molecular Physiology and Biological Physics at University of Virginia
    Proactive validation of macromolecular structures
12:00 AM – 1:00 PM Box lunches delivered
Break down of posters and exhibits by 1:00
1:00 PM – 4:00 PM Structure Determination Workshop - Hosted by Wladek Minor's Laboratory
Jordan Hall, 4th Floor, Somlyo Conference Room

CryoEM Demonstration - Hosted by Mark Yeager’s Laboratory & the Molecular Electron Microscopy Core
Snyder Building, Fontaine Research Park